The Bowen–Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Ψ1191 in yeast 18S rRNA

The Nep1 (Emg1) SPOUT-class methyltransferase is an essential ribosome assembly factor and the human Bowen–Conradi syndrome (BCS) is caused by a specific Nep1(D86G) mutation. We recently showed in vitro that Methanocaldococcus jannaschii Nep1 is a sequence-specific pseudouridine-N1-methyltransferase...

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Detalles Bibliográficos
Autores principales: Meyer, Britta, Wurm, Jan Philip, Kötter, Peter, Leisegang, Matthias S., Schilling, Valeska, Buchhaupt, Markus, Held, Martin, Bahr, Ute, Karas, Michael, Heckel, Alexander, Bohnsack, Markus T., Wöhnert, Jens, Entian, Karl-Dieter
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045603/
https://www.ncbi.nlm.nih.gov/pubmed/20972225
http://dx.doi.org/10.1093/nar/gkq931

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045603/
https://www.ncbi.nlm.nih.gov/pubmed/20972225
http://dx.doi.org/10.1093/nar/gkq931

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