Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5′ triphosphate

RIG-I recognizes molecular patterns in viral RNA to regulate the induction of type I interferons. The C-terminal domain (CTD) of RIG-I exhibits high affinity for 5′ triphosphate (ppp) dsRNA as well as blunt-ended dsRNA. Structures of RIG-I CTD bound to 5′-ppp dsRNA showed that RIG-I recognizes the t...

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Detalles Bibliográficos
Autores principales: Lu, Cheng, Ranjith-Kumar, C. T., Hao, Lujiang, Kao, C. Cheng, Li, Pingwei
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045611/
https://www.ncbi.nlm.nih.gov/pubmed/20961956
http://dx.doi.org/10.1093/nar/gkq974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045611/
https://www.ncbi.nlm.nih.gov/pubmed/20961956
http://dx.doi.org/10.1093/nar/gkq974

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