Meiotic recombination protein Rec12: functional conservation, crossover homeostasis and early crossover/non-crossover decision

In fission yeast and other eukaryotes, Rec12 (Spo11) is thought to catalyze the formation of dsDNA breaks (DSBs) that initiate homologous recombination in meiosis. Rec12 is orthologous to the catalytic subunit of topoisomerase VI (Top6A). Guided by the crystal structure of Top6A, we engineered the r...

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Detalles Bibliográficos
Autores principales: Kan, Fengling, Davidson, Mari K., Wahls, Wayne P.
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045620/
https://www.ncbi.nlm.nih.gov/pubmed/21030440
http://dx.doi.org/10.1093/nar/gkq993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045620/
https://www.ncbi.nlm.nih.gov/pubmed/21030440
http://dx.doi.org/10.1093/nar/gkq993

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