Synergism between DNA methylation and macroH2A1 occupancy in epigenetic silencing of the tumor suppressor gene p16(CDKN2A)

Promoter hypermethylation and heterochromatinization is a frequent event leading to gene inactivation and tumorigenesis. At the molecular level, inactivation of tumor suppressor genes in cancer has many similarities to the inactive X chromosome in female cells and is defined and maintained by DNA me...

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Detalles Bibliográficos
Autores principales: Barzily-Rokni, Michal, Friedman, Nathalie, Ron-Bigger, Shulamit, Isaac, Sara, Michlin, Dan, Eden, Amir
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045621/
https://www.ncbi.nlm.nih.gov/pubmed/21030442
http://dx.doi.org/10.1093/nar/gkq994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045621/
https://www.ncbi.nlm.nih.gov/pubmed/21030442
http://dx.doi.org/10.1093/nar/gkq994

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