Mono- and tri-cationic porphyrin–monoclonal antibody conjugates: photodynamic activity and mechanism of action

Two cationic porphyrins bearing an isothiocyanate group for conjugation to monocolonal antibodies have been synthesized. The two porphyrins conjugated efficiently to three monoclonal antibodies (anti-CD104, anti-CD146 and anti-CD326), which recognize antigens commonly over-expressed on a range of tu...

Descripción completa

Detalles Bibliográficos
Autores principales: Smith, Karen, Malatesti, Nela, Cauchon, Nicole, Hunting, Darel, Lecomte, Roger, van Lier, Johan E, Greenman, John, Boyle, Ross W
Formato: Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2011
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045661/
https://www.ncbi.nlm.nih.gov/pubmed/21039468
http://dx.doi.org/10.1111/j.1365-2567.2010.03359.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045661/
https://www.ncbi.nlm.nih.gov/pubmed/21039468
http://dx.doi.org/10.1111/j.1365-2567.2010.03359.x

Ejemplares similares