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Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity

Within the last 3 years, genome-wide association studies (GWAS) have had unprecedented success in identifying loci that are involved in common diseases. For example, more than 35 susceptibility loci have been identified for type 2 diabetes and 32 for obesity thus far. However, the causal gene and va...

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Detalles Bibliográficos
Autores principales: Cox, Roger D., Church, Christopher D.
Formato: Texto
Lenguaje:English
Publicado: The Company of Biologists Limited 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046087/
https://www.ncbi.nlm.nih.gov/pubmed/21324932
http://dx.doi.org/10.1242/dmm.000414