Frequent and Simultaneous Epigenetic Inactivation of TP53 Pathway Genes in Acute Lymphoblastic Leukemia

Aberrant DNA methylation is one of the most frequent alterations in patients with Acute Lymphoblastic Leukemia (ALL). Using methylation bead arrays we analyzed the methylation status of 807 genes implicated in cancer in a group of ALL samples at diagnosis (n = 48). We found that 154 genes were methy...

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Detalles Bibliográficos
Autores principales: Vilas–Zornoza, Amaia, Agirre, Xabier, Martín-Palanco, Vanesa, Martín-Subero, José Ignacio, San José-Eneriz, Edurne, Garate, Leire, Álvarez, Sara, Miranda, Estíbaliz, Rodríguez-Otero, Paula, Rifón, José, Torres, Antonio, Calasanz, María José, Cigudosa, Juan Cruz, Román-Gómez, José, Prósper, Felipe
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046174/
https://www.ncbi.nlm.nih.gov/pubmed/21386967
http://dx.doi.org/10.1371/journal.pone.0017012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046174/
https://www.ncbi.nlm.nih.gov/pubmed/21386967
http://dx.doi.org/10.1371/journal.pone.0017012

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