Hepatic Deletion of Smad7 in Mouse Leads to Spontaneous Liver Dysfunction and Aggravates Alcoholic Liver Injury

BACKGROUND: TGF-β has been known to play an important role in various liver diseases including fibrosis and alcohol-induced fatty liver. Smad7 is an intracellular negative regulator of TGF-β signaling. It is currently unclear whether endogenous Smad7 has an effect on liver function and alcoholic liv...

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Detalles Bibliográficos
Autores principales: Zhu, Lu, Wang, Lingdi, Wang, Xiao, Luo, Xiaolin, Yang, Ling, Zhang, Rui, Yin, Hongkun, Xie, Dong, Pan, Yi, Chen, Yan
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046253/
https://www.ncbi.nlm.nih.gov/pubmed/21386907
http://dx.doi.org/10.1371/journal.pone.0017415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046253/
https://www.ncbi.nlm.nih.gov/pubmed/21386907
http://dx.doi.org/10.1371/journal.pone.0017415

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