Cargando…

Hepatic Deletion of Smad7 in Mouse Leads to Spontaneous Liver Dysfunction and Aggravates Alcoholic Liver Injury

BACKGROUND: TGF-β has been known to play an important role in various liver diseases including fibrosis and alcohol-induced fatty liver. Smad7 is an intracellular negative regulator of TGF-β signaling. It is currently unclear whether endogenous Smad7 has an effect on liver function and alcoholic liv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Lu, Wang, Lingdi, Wang, Xiao, Luo, Xiaolin, Yang, Ling, Zhang, Rui, Yin, Hongkun, Xie, Dong, Pan, Yi, Chen, Yan
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046253/ https://www.ncbi.nlm.nih.gov/pubmed/21386907 http://dx.doi.org/10.1371/journal.pone.0017415

Ejemplares similares

Liver-specific deletion of RORα aggravates diet-induced nonalcoholic steatohepatitis by inducing mitochondrial dysfunction
por: Kim, Hyeon-Ji, et al.
Publicado: (2017)

Oxaliplatin aggravates hepatic oxidative stress, inflammation and fibrosis in a non-alcoholic fatty liver disease mouse model
por: Lu, Yulei, et al.
Publicado: (2019)

Liver-Specific Deletion of Mouse CTCF Leads to Hepatic Steatosis via Augmented PPARγ Signaling
por: Choi, Yeeun, et al.
Publicado: (2021)

In Vivo Disruption of TGF-β Signaling by Smad7 in Airway Epithelium Alleviates Allergic Asthma but Aggravates Lung Carcinogenesis in Mouse
por: Luo, Xiaolin, et al.
Publicado: (2010)

Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct–Ligated Mouse
por: Cai, Shi-Ying, et al.
Publicado: (2019)

Liver-specific deletion of Eva1a/Tmem166 aggravates acute liver injury by impairing autophagy
por: Lin, Xin, et al.
Publicado: (2018)

Alcohol Abuse and Alcoholic Liver Cirrhosis Leading to Spontaneous Muscle Hematoma: An Event Fraught with Danger
por: Mangla, Ankit, et al.
Publicado: (2015)

Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Viral Hepatitis
por: Wang, Xiaolin, et al.
Publicado: (2022)

Vitamin D Deficiency Aggravates Hepatic Oxidative Stress and Inflammation during Chronic Alcohol-Induced Liver Injury in Mice
por: Hu, Chun-Qiu, et al.
Publicado: (2020)

The mechanism of dysbiosis in alcoholic liver disease leading to liver cancer
por: Méndez-Sánchez, Nahum, et al.
Publicado: (2020)

Osteopontin deletion drives hematopoietic stem cell mobilization to the liver and increases hepatic iron contributing to alcoholic liver disease
por: Magdaleno, Fernando, et al.
Publicado: (2017)

IL-12p40 deletion aggravates lipopolysaccharide-induced cardiac dysfunction in mice
por: Liu, Menglin, et al.
Publicado: (2022)

Spontaneous Evolution in Bilirubin Levels Predicts Liver-Related Mortality in Patients with Alcoholic Hepatitis
por: Lee, Minjong, et al.
Publicado: (2014)

Deleted in Liver Cancer 2 (DLC2) Was Dispensable for Development and Its Deficiency Did Not Aggravate Hepatocarcinogenesis
por: Yau, Tai On, et al.
Publicado: (2009)

Loss of hepatic Mboat7 leads to liver fibrosis
por: Thangapandi, Veera Raghavan, et al.
Publicado: (2021)

Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway
por: Ma, Chunxiao, et al.
Publicado: (2023)

SIRT6 Protects Against Liver Fibrosis by Deacetylation and Suppression of SMAD3 in Hepatic Stellate Cells
por: Zhong, Xiaolin, et al.
Publicado: (2020)

Liver Transplantation for Hepatitis C and Alcoholic Liver Disease
por: Carbone, Marco, et al.
Publicado: (2010)

Alcoholic liver steatosis in mice is aggravated by low-protein diet and reversed by FXR agonist
por: Lívero, Francislaine Aparecida dos Reis, et al.
Publicado: (2012)

Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease
por: Leung, Christopher, et al.
Publicado: (2016)

Cholesterol-Induced Non-Alcoholic Fatty Liver Disease and Atherosclerosis Aggravated by Systemic Inflammation
por: Kim, Eung Ju, et al.
Publicado: (2014)

Sirt1 Deletion Leads to Enhanced Inflammation and Aggravates Endotoxin-Induced Acute Kidney Injury
por: Gao, Rong, et al.
Publicado: (2014)

Aryl Hydrocarbon Receptor Deficiency in Intestinal Epithelial Cells Aggravates Alcohol-Related Liver Disease
por: Qian, Minyi, et al.
Publicado: (2021)

Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet
por: Lambooy, Sebastiaan, et al.
Publicado: (2023)

Dysregulation of intercellular signaling by MOF deletion leads to liver injury
por: Lei, Hongwei, et al.
Publicado: (2021)

Il12a Deletion Aggravates Sepsis-Induced Cardiac Dysfunction by Regulating Macrophage Polarization
por: Wang, Zhen, et al.
Publicado: (2021)

Hepatic Nampt Deficiency Aggravates Dyslipidemia and Fatty Liver in High Fat Diet Fed Mice
por: Wang, Dao-Xin, et al.
Publicado: (2023)

Correction: Spontaneous Evolution in Bilirubin Levels Predicts Liver-Related Mortality in Patients with Alcoholic Hepatitis
por: Lee, Minjong, et al.
Publicado: (2016)

Genetic Deletion of the LINC00520 Homolog in Mouse Aggravates Angiotensin II-Induced Hypertension
por: Tang, Xiaofang, et al.
Publicado: (2023)

Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver
por: Gerjevic, Lisa Nicole, et al.
Publicado: (2012)

Liver fibrogenesis due to cholestasis is associated with increased Smad7 expression and Smad3 signaling
por: Seyhan, H, et al.
Publicado: (2006)

Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury
por: Liu, Xiaoying, et al.
Publicado: (2022)

Indole-3-propionic Acid-aggravated CCl(4)-induced Liver Fibrosis via the TGF-β1/Smads Signaling Pathway
por: Liu, Fei, et al.
Publicado: (2021)

Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver
por: Yokota, Shin-Ichi, et al.
Publicado: (2014)

Comprehensive Analysis of the Expression Profiles of Hepatic lncRNAs in the Mouse Model of Alcoholic Liver Disease
por: Dou, Xiaobing, et al.
Publicado: (2021)

Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver
por: Wang, Lina, et al.
Publicado: (2017)

How does hepatic lipid accumulation lead to lipotoxicity in non-alcoholic fatty liver disease?
por: Geng, Yana, et al.
Publicado: (2021)

Nonylphenol aggravates non-alcoholic fatty liver disease in high sucrose-high fat diet-treated rats
por: Yu, Jie, et al.
Publicado: (2018)

Ramipril: Aggravation of liver toxicity: case report
Publicado: (2020)

Targeted Deletion of Thymosin Beta 4 in Hepatic Stellate Cells Ameliorates Liver Fibrosis in a Transgenic Mouse Model
por: Kim, Jieun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_425o241tpgb45aoief2eqkhf3f