Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice

OBJECTIVE: AMP-activated protein kinase (AMPK) signaling acts as a sensor of nutrients and hormones in the hypothalamus, thereby regulating whole-body energy homeostasis. Deletion of Ampkα2 in pro-opiomelanocortin (POMC) neurons causes obesity and defective neuronal glucose sensing. LKB1, the Peutz-...

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Detalles Bibliográficos
Autores principales: Claret, Marc, Smith, Mark A., Knauf, Claude, Al-Qassab, Hind, Woods, Angela, Heslegrave, Amanda, Piipari, Kaisa, Emmanuel, Julian J., Colom, André, Valet, Philippe, Cani, Patrice D., Begum, Ghazala, White, Anne, Mucket, Phillip, Peters, Marco, Mizuno, Keiko, Batterham, Rachel L., Giese, K. Peter, Ashworth, Alan, Burcelin, Remy, Ashford, Michael L., Carling, David, Withers, Dominic J.
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046834/
https://www.ncbi.nlm.nih.gov/pubmed/21266325
http://dx.doi.org/10.2337/db10-1055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046834/
https://www.ncbi.nlm.nih.gov/pubmed/21266325
http://dx.doi.org/10.2337/db10-1055

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