Chronic Methylglyoxal Infusion by Minipump Causes Pancreatic β-Cell Dysfunction and Induces Type 2 Diabetes in Sprague-Dawley Rats

OBJECTIVE: The incidence of high dietary carbohydrate-induced type 2 diabetes is increasing worldwide. Methylglyoxal (MG) is a reactive glucose metabolite and a major precursor of advanced glycation end products (AGEs). MG levels are elevated in diabetic patients. We investigated the effects of chro...

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Detalles Bibliográficos
Autores principales: Dhar, Arti, Dhar, Indu, Jiang, Bo, Desai, Kaushik M., Wu, Lingyun
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Pathophysiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046851/
https://www.ncbi.nlm.nih.gov/pubmed/21300844
http://dx.doi.org/10.2337/db10-0627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046851/
https://www.ncbi.nlm.nih.gov/pubmed/21300844
http://dx.doi.org/10.2337/db10-0627

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