Cdc45 Limits Replicon Usage from a Low Density of preRCs in Mammalian Cells

Little is known about mammalian preRC stoichiometry, the number of preRCs on chromosomes, and how this relates to replicon size and usage. We show here that, on average, each 100-kb of the mammalian genome contains a preRC composed of approximately one ORC hexamer, 4–5 MCM hexamers, and 2 Cdc6. Rela...

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Detalles Bibliográficos
Autores principales: Wong, Philip G., Winter, Sherry L., Zaika, Elena, Cao, Thinh V., Oguz, Umut, Koomen, John M., Hamlin, Joyce L., Alexandrow, Mark G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046982/
https://www.ncbi.nlm.nih.gov/pubmed/21390258
http://dx.doi.org/10.1371/journal.pone.0017533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046982/
https://www.ncbi.nlm.nih.gov/pubmed/21390258
http://dx.doi.org/10.1371/journal.pone.0017533

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