Ca(2+)-Dependent Phosphorylation of RyR2 Can Uncouple Channel Gating from Direct Cytosolic Ca(2+) Regulation

Phosphorylation of the cardiac ryanodine receptor (RyR2) is thought to be important not only for normal cardiac excitation-contraction coupling but also in exacerbating abnormalities in Ca(2+) homeostasis in heart failure. Linking phosphorylation to specific changes in the single-channel function of...

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Detalles Bibliográficos
Autores principales: Carter, Simon, Pitt, Samantha J., Colyer, John, Sitsapesan, Rebecca
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047053/
https://www.ncbi.nlm.nih.gov/pubmed/21274522
http://dx.doi.org/10.1007/s00232-011-9339-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047053/
https://www.ncbi.nlm.nih.gov/pubmed/21274522
http://dx.doi.org/10.1007/s00232-011-9339-9

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