p53 governs telomere regulation feedback too, via TRF2

p53 takes critical part in a number of positive and negative feedback loops to regulate carcinogenesis, aging and other biological processes. Uncapped or dysfunctional telomeres are an endogenous DNA damage that activates ATM kinase (ataxia telangiectasia mutated) and then p53 to induce cellular sen...

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Detalles Bibliográficos
Autores principales: Horikawa, Izumi, Fujita, Kaori, Harris, Curtis C.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047136/
https://www.ncbi.nlm.nih.gov/pubmed/21266744

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3047136/
https://www.ncbi.nlm.nih.gov/pubmed/21266744

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