Dynamic Conformational Changes in MUNC18 Prevent Syntaxin Binding

The Sec1/munc18 protein family is essential for vesicle fusion in eukaryotic cells via binding to SNARE proteins. Protein kinase C modulates these interactions by phosphorylating munc18a thereby reducing its affinity to one of the central SNARE members, syntaxin-1a. The established hypothesis is tha...

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Detalles Bibliográficos
Autores principales: Bar-On, Dana, Nachliel, Esther, Gutman, Menachem, Ashery, Uri
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048386/
https://www.ncbi.nlm.nih.gov/pubmed/21390273
http://dx.doi.org/10.1371/journal.pcbi.1001097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048386/
https://www.ncbi.nlm.nih.gov/pubmed/21390273
http://dx.doi.org/10.1371/journal.pcbi.1001097

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