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SNF5, a core component of the Swi/Snf complex, is necessary for p53 expression and cell survival in part via eIF4E
SNF5, a core component of the SWI/SNF chromatin remodeling complex, is expressed as two isoforms, SNF5a and SNF5b. SNF5 is a tumor suppressor as mutation of SNF5 leads to tumor formation and cooperates with p53 deficiency to enhance cancer susceptibility. Interestingly, lack of SNF5 inhibits cell su...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049166/ https://www.ncbi.nlm.nih.gov/pubmed/20473326 http://dx.doi.org/10.1038/onc.2010.159 |