SNF5, a core component of the Swi/Snf complex, is necessary for p53 expression and cell survival in part via eIF4E

SNF5, a core component of the SWI/SNF chromatin remodeling complex, is expressed as two isoforms, SNF5a and SNF5b. SNF5 is a tumor suppressor as mutation of SNF5 leads to tumor formation and cooperates with p53 deficiency to enhance cancer susceptibility. Interestingly, lack of SNF5 inhibits cell su...

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Detalles Bibliográficos
Autores principales: Xu, Yang, Yan, Wensheng, Chen, Xinbin
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049166/
https://www.ncbi.nlm.nih.gov/pubmed/20473326
http://dx.doi.org/10.1038/onc.2010.159

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