Small RNA-mediated regulation of iPS cell generation

Somatic cells can be reprogrammed to an ES-like state to create induced pluripotent stem cells (iPSCs) by ectopic expression of four transcription factors, Oct4, Sox2, Klf4 and cMyc. Here, we show that cellular microRNAs (miRNAs) regulate iPSC generation. Knock-down of key microRNA pathway proteins...

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Detalles Bibliográficos
Autores principales: Li, Zhonghan, Yang, Chao-Shun, Nakashima, Katsuhiko, Rana, Tariq M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049216/
https://www.ncbi.nlm.nih.gov/pubmed/21285944
http://dx.doi.org/10.1038/emboj.2011.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049216/
https://www.ncbi.nlm.nih.gov/pubmed/21285944
http://dx.doi.org/10.1038/emboj.2011.2

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