Polyclonality of BRAF mutations in primary melanoma and the selection of mutant alleles during progression

BACKGROUND: Oncogenic BRAF mutation had been considered to be a founder event in the formation of melanocytic tumours; however, we recently argued against this notion by showing marked polyclonality of BRAF mutations in acquired melanocytic nevi (Lin et al, J Natl Cancer Inst., 2009; 101:1423–7). He...

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Detalles Bibliográficos
Autores principales: Lin, J, Goto, Y, Murata, H, Sakaizawa, K, Uchiyama, A, Saida, T, Takata, M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049568/
https://www.ncbi.nlm.nih.gov/pubmed/21224857
http://dx.doi.org/10.1038/sj.bjc.6606072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049568/
https://www.ncbi.nlm.nih.gov/pubmed/21224857
http://dx.doi.org/10.1038/sj.bjc.6606072

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