Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell lines

AIMS: Modulation of DNA base excision repair (BER) has the potential to enhance response to chemotherapy and improve outcomes in tumours such as melanoma and glioma. APE1, a critical protein in BER that processes potentially cytotoxic abasic sites (AP sites), is a promising new target in cancer. In...

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Detalles Bibliográficos
Autores principales: Mohammed, M Z, Vyjayanti, V N, Laughton, C A, Dekker, L V, Fischer, P M, Wilson, D M, Abbotts, R, Shah, S, Patel, P M, Hickson, I D, Madhusudan, S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049581/
https://www.ncbi.nlm.nih.gov/pubmed/21266972
http://dx.doi.org/10.1038/sj.bjc.6606058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049581/
https://www.ncbi.nlm.nih.gov/pubmed/21266972
http://dx.doi.org/10.1038/sj.bjc.6606058

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