Azacytidine and Decitabine Induce Gene-Specific and Non-Random DNA Demethylation in Human Cancer Cell Lines

The DNA methyltransferase inhibitors azacytidine and decitabine represent archetypal drugs for epigenetic cancer therapy. To characterize the demethylating activity of azacytidine and decitabine we treated colon cancer and leukemic cells with both drugs and used array-based DNA methylation analysis...

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Detalles Bibliográficos
Autores principales: Hagemann, Sabine, Heil, Oliver, Lyko, Frank, Brueckner, Bodo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049766/
https://www.ncbi.nlm.nih.gov/pubmed/21408221
http://dx.doi.org/10.1371/journal.pone.0017388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049766/
https://www.ncbi.nlm.nih.gov/pubmed/21408221
http://dx.doi.org/10.1371/journal.pone.0017388

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