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Unfolding of the Amyloid β-Peptide Central Helix: Mechanistic Insights from Molecular Dynamics Simulations

Alzheimer's disease (AD) pathogenesis is associated with formation of amyloid fibrils caused by polymerization of the amyloid β-peptide (Aβ), which is a process that requires unfolding of the native helical structure of Aβ. According to recent experimental studies, stabilization of the Aβ centr...

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Detalles Bibliográficos
Autores principales: Ito, Mika, Johansson, Jan, Strömberg, Roger, Nilsson, Lennart
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049775/
https://www.ncbi.nlm.nih.gov/pubmed/21408230
http://dx.doi.org/10.1371/journal.pone.0017587