Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging

BACKGROUND: Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to be a principal mechanism of aging. Here we tested this hypothesis in healthy individuals of different ages by examining unrepaired DNA double-strand breaks (DSBs) in hematopoietic stem/progenitor cells...

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Detalles Bibliográficos
Autores principales: Rübe, Claudia E., Fricke, Andreas, Widmann, Thomas A., Fürst, Tobias, Madry, Henning, Pfreundschuh, Michael, Rübe, Christian
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049780/
https://www.ncbi.nlm.nih.gov/pubmed/21408175
http://dx.doi.org/10.1371/journal.pone.0017487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049780/
https://www.ncbi.nlm.nih.gov/pubmed/21408175
http://dx.doi.org/10.1371/journal.pone.0017487

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