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Accumulation of DNA Damage in Hematopoietic Stem and Progenitor Cells during Human Aging
BACKGROUND: Accumulation of DNA damage leading to adult stem cell exhaustion has been proposed to be a principal mechanism of aging. Here we tested this hypothesis in healthy individuals of different ages by examining unrepaired DNA double-strand breaks (DSBs) in hematopoietic stem/progenitor cells...
Autores principales: | Rübe, Claudia E., Fricke, Andreas, Widmann, Thomas A., Fürst, Tobias, Madry, Henning, Pfreundschuh, Michael, Rübe, Christian |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049780/ https://www.ncbi.nlm.nih.gov/pubmed/21408175 http://dx.doi.org/10.1371/journal.pone.0017487 |
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