Early T Cell Signalling Is Reversibly Altered in PD-1(+) T Lymphocytes Infiltrating Human Tumors

To improve cancer immunotherapy, a better understanding of the weak efficiency of tumor-infiltrating T lymphocytes (TIL) is necessary. We have analyzed the functional state of human TIL immediately after resection of three types of tumors (NSCLC, melanoma and RCC). Several signalling pathways (calci...

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Detalles Bibliográficos
Autores principales: Wang, Shu-Fang, Fouquet, Stéphane, Chapon, Maxime, Salmon, Hélène, Regnier, Fabienne, Labroquère, Karine, Badoual, Cécile, Damotte, Diane, Validire, Pierre, Maubec, Eve, Delongchamps, Nicolas B., Cazes, Aurélie, Gibault, Laure, Garcette, Marylène, Dieu-Nosjean, Marie-Caroline, Zerbib, Marc, Avril, Marie-Françoise, Prévost-Blondel, Armelle, Randriamampita, Clotilde, Trautmann, Alain, Bercovici, Nadège
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049782/
https://www.ncbi.nlm.nih.gov/pubmed/21408177
http://dx.doi.org/10.1371/journal.pone.0017621

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