Two-stage designs optimal under the alternative hypothesis for phase II cancer clinical trials

The Simon two-stage optimal design is often used for phase II cancer clinical trials. A study proceeds to the second stage unless the null hypothesis, that the true tumour response rate is below some specified value, is already accepted at the end of stage one. The conventional optimal design, for g...

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Detalles Bibliográficos
Autores principales: Mander, A.P., Thompson, S.G.
Formato: Texto
Lenguaje:English
Publicado: Elsevier 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049867/
https://www.ncbi.nlm.nih.gov/pubmed/20678585
http://dx.doi.org/10.1016/j.cct.2010.07.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049867/
https://www.ncbi.nlm.nih.gov/pubmed/20678585
http://dx.doi.org/10.1016/j.cct.2010.07.008

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