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Two-stage designs optimal under the alternative hypothesis for phase II cancer clinical trials
The Simon two-stage optimal design is often used for phase II cancer clinical trials. A study proceeds to the second stage unless the null hypothesis, that the true tumour response rate is below some specified value, is already accepted at the end of stage one. The conventional optimal design, for g...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049867/ https://www.ncbi.nlm.nih.gov/pubmed/20678585 http://dx.doi.org/10.1016/j.cct.2010.07.008 |