Cargando…

Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKα2 in the regulation of exercise capacity in vivo

OBJECTIVE: Skeletal muscle AMP-activated protein kinase (AMPK)α2 activity is impaired in obese, insulin resistant individuals during exercise. We determined whether this defect contributes to the metabolic dysregulation and reduced exercise capacity observed in the obese state. DESIGN: C57BL/6J wild...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee-Young, Robert S., Ayala, Julio E., Fueger, Patrick T., Mayes, Wesley H., Kang, Li, Wasserman, David H.
Formato:	Texto
Lenguaje:	English
Publicado:	2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049903/ https://www.ncbi.nlm.nih.gov/pubmed/21079619 http://dx.doi.org/10.1038/ijo.2010.220

Ejemplares similares

The AMPK activator R419 improves exercise capacity and skeletal muscle insulin sensitivity in obese mice
por: Marcinko, Katarina, et al.
Publicado: (2015)

AMPK is required for exercise to enhance insulin sensitivity in skeletal muscles
por: Jensen, Jørgen, et al.
Publicado: (2017)

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK
por: Fu, Xing, et al.
Publicado: (2016)

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise
por: Hingst, Janne R., et al.
Publicado: (2020)

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1α in skeletal muscle
por: Palacios, Orsolya M., et al.
Publicado: (2009)

Effects of Thiamin Restriction on Exercise-Associated Glycogen Metabolism and AMPK Activation Level in Skeletal Muscle
por: Sato, Akiko, et al.
Publicado: (2022)

AMPK in skeletal muscle function and metabolism
por: Kjøbsted, Rasmus, et al.
Publicado: (2018)

Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver
por: Muise, Eric S., et al.
Publicado: (2019)

Exercise Increases Insulin Sensitivity and Skeletal Muscle AMPK Expression in Systemic Lupus Erythematosus: A Randomized Controlled Trial
por: Benatti, Fabiana B., et al.
Publicado: (2018)

Role of AMPKα in Skeletal Muscle Glycometabolism Regulation and Adaptation in relation to Sepsis
por: Zheng, Xia, et al.
Publicado: (2014)

BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1α signaling in heart failure mice
por: Zhang, Zheng, et al.
Publicado: (2018)

AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
por: O'Neill, Hayley M.
Publicado: (2013)

Disrupting AMPK-Glycogen Binding in Mice Increases Carbohydrate Utilization and Reduces Exercise Capacity
por: Janzen, Natalie R., et al.
Publicado: (2022)

Localisation of AMPK γ subunits in cardiac and skeletal muscles
por: Pinter, Katalin, et al.
Publicado: (2013)

CARM1 Regulates AMPK Signaling in Skeletal Muscle
por: Stouth, Derek W., et al.
Publicado: (2020)

Exercise-induced metabolic fluctuations influence AMPK, p38-MAPK and CaMKII phosphorylation in human skeletal muscle
por: Combes, Adrien, et al.
Publicado: (2015)

Time since menopause and skeletal muscle estrogen receptors, PGC-1α, and AMPK
por: Park, Young-Min, et al.
Publicado: (2017)

Tlr9 and Beclin 1 Cross-Talk Regulates Muscle AMPK Activation in Exercise
por: Liu, Yang, et al.
Publicado: (2020)

Hypoxia impairs adaptation of skeletal muscle protein turnover- and AMPK signaling during fasting-induced muscle atrophy
por: de Theije, C. C., et al.
Publicado: (2018)

AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
por: Ericsson, Madelene, et al.
Publicado: (2021)

Cardiac Fibrosis Alleviated by Exercise Training Is AMPK-Dependent
por: Ma, Xiaowei, et al.
Publicado: (2015)

Exercise and Mitochondrial Dynamics: Keeping in Shape with ROS and AMPK
por: Trewin, Adam J., et al.
Publicado: (2018)

Skeletal muscle AMPK is essential for the maintenance of FNDC5 expression
por: Lally, James S V, et al.
Publicado: (2015)

The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
por: Thomson, David M.
Publicado: (2018)

Elevated Nicotinamide Phosphoribosyl Transferase in Skeletal Muscle Augments Exercise Performance and Mitochondrial Respiratory Capacity Following Exercise Training
por: Brouwers, Bram, et al.
Publicado: (2018)

SAT639 Electronic Cigarettes-exposed Mice Have Impairments In Skeletal Muscle Mediated By Impaired Ampk Activation
por: Rivera, Juan Carlos, et al.
Publicado: (2023)

Skeletal muscle AMPK is not activated during 2 h of moderate intensity exercise at ∼65% [Formula: see text] in endurance trained men
por: McConell, Glenn K., et al.
Publicado: (2020)

Activation of AMPKα2 Is Not Required for Mitochondrial FAT/CD36 Accumulation during Exercise
por: Monaco, Cynthia, et al.
Publicado: (2015)

The Role of Nrf2 in Skeletal Muscle on Exercise Capacity
por: Kitaoka, Yu
Publicado: (2021)

Maternal Exercise Mediates Hepatic Metabolic Programming via Activation of AMPK-PGC1α Axis in the Offspring of Obese Mothers
por: Kasper, Philipp, et al.
Publicado: (2021)

Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling
por: Son, Jun Seok, et al.
Publicado: (2022)

Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats
por: Qi, Yong, et al.
Publicado: (2014)

Exercise preserves physical fitness during aging through AMPK and mitochondrial dynamics
por: Campos, Juliane Cruz, et al.
Publicado: (2023)

Myogenin Regulates Exercise Capacity and Skeletal Muscle Metabolism in the Adult Mouse
por: Flynn, Jesse M., et al.
Publicado: (2010)

Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats
por: Coughlan, Kimberly A., et al.
Publicado: (2015)

The Effect of Aerobic Exercise on the Oxidative Capacity of Skeletal Muscle Mitochondria in Mice with Impaired Glucose Tolerance
por: Wang, Dan, et al.
Publicado: (2022)

Saffron with resistance exercise improves diabetic parameters through the GLUT4/AMPK pathway in-vitro and in-vivo
por: Dehghan, Firouzeh, et al.
Publicado: (2016)

Raspberry alleviates obesity-induced inflammation and insulin resistance in skeletal muscle through activation of AMP-activated protein kinase (AMPK) α1
por: Zhao, Liang, et al.
Publicado: (2018)

Central Exercise Action Increases the AMPK and mTOR Response to Leptin
por: Ropelle, Eduardo R., et al.
Publicado: (2008)

LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK
por: Jeppesen, Jacob, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_70qrnntdutnb7bigc5es9q2n7q