Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts

PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy. Here, we investigated the impact of mutati...

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Detalles Bibliográficos
Autores principales: Rakovic, Aleksandar, Grünewald, Anne, Kottwitz, Jan, Brüggemann, Norbert, Pramstaller, Peter P., Lohmann, Katja, Klein, Christine
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050809/
https://www.ncbi.nlm.nih.gov/pubmed/21408142
http://dx.doi.org/10.1371/journal.pone.0016746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050809/
https://www.ncbi.nlm.nih.gov/pubmed/21408142
http://dx.doi.org/10.1371/journal.pone.0016746

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