Cargando…

Mutations in PINK1 and Parkin Impair Ubiquitination of Mitofusins in Human Fibroblasts

PINK1 and Parkin mutations cause recessive Parkinson's disease (PD). In Drosophila and SH-SY5Y cells, Parkin is recruited by PINK1 to damaged mitochondria, where it ubiquitinates Mitofusins and consequently promotes mitochondrial fission and mitophagy. Here, we investigated the impact of mutati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rakovic, Aleksandar, Grünewald, Anne, Kottwitz, Jan, Brüggemann, Norbert, Pramstaller, Peter P., Lohmann, Katja, Klein, Christine
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050809/ https://www.ncbi.nlm.nih.gov/pubmed/21408142 http://dx.doi.org/10.1371/journal.pone.0016746

Ejemplares similares

Mutant Parkin Impairs Mitochondrial Function and Morphology in Human Fibroblasts
por: Grünewald, Anne, et al.
Publicado: (2010)

PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1
por: Rakovic, Aleksandar, et al.
Publicado: (2011)

MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
por: Yun, Jina, et al.
Publicado: (2014)

The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway
por: Poole, Angela C., et al.
Publicado: (2010)

Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson's disease
por: Celardo, I, et al.
Publicado: (2016)

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy
por: McLelland, Gian-Luca, et al.
Publicado: (2018)

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity
por: Kane, Lesley A., et al.
Publicado: (2014)

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser(65)
por: Kazlauskaite, Agne, et al.
Publicado: (2014)

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
por: Shiba-Fukushima, Kahori, et al.
Publicado: (2012)

New Perception of Mitochondrial Regulatory Pathway in Parkinsonism – Ubiquitin, PINK1, and Parkin
por: Olszewska, Diana Angelika, et al.
Publicado: (2014)

Profiling of Parkin-Binding Partners Using Tandem Affinity Purification
por: Zanon, Alessandra, et al.
Publicado: (2013)

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
por: Narendra, Derek P., et al.
Publicado: (2010)

Regulatory Roles of PINK1-Parkin and AMPK in Ubiquitin-Dependent Skeletal Muscle Mitophagy
por: Seabright, Alex P., et al.
Publicado: (2020)

Parkin and PINK1 mitigate STING-induced inflammation
por: Sliter, Danielle A., et al.
Publicado: (2018)

Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
por: Cornelissen, Tom, et al.
Publicado: (2018)

Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells
por: Guida, Marianna, et al.
Publicado: (2019)

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
por: Tanaka, Atsushi, et al.
Publicado: (2010)

PINK1-Mediated Phosphorylation of Parkin Boosts Parkin Activity in Drosophila
por: Shiba-Fukushima, Kahori, et al.
Publicado: (2014)

The Roles of PINK1 and Parkin in Parkinson's Disease
por: Jones, Rachel
Publicado: (2010)

PINK1 and Parkin to control mitochondria remodeling
por: Koh, Hyongjong, et al.
Publicado: (2010)

PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
por: Quinn, Peter M. J., et al.
Publicado: (2020)

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation
por: Kazlauskaite, Agne, et al.
Publicado: (2015)

Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria
por: Vranas, Marta, et al.
Publicado: (2022)

ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts
por: Qi, Yongmei, et al.
Publicado: (2016)

PINK1-Parkin Pathway Activity Is Regulated by Degradation of PINK1 in the Mitochondrial Matrix
por: Thomas, Ruth E., et al.
Publicado: (2014)

PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control
por: Zhuang, Na, et al.
Publicado: (2016)

Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin
por: Caulfield, Thomas R., et al.
Publicado: (2014)

PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy
por: Wang, Liming, et al.
Publicado: (2018)

Mitophagy and Parkinson's disease: The PINK1–parkin link()
por: Deas, Emma, et al.
Publicado: (2011)

Mitochondrial quality control beyond PINK1/Parkin
por: von Stockum, Sophia, et al.
Publicado: (2018)

Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
por: Xiao, Bin, et al.
Publicado: (2017)

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy
por: Lee, Joo-Yong, et al.
Publicado: (2010)

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
por: Matsuda, Noriyuki, et al.
Publicado: (2010)

Correction: Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria
por: Xiao, Bin, et al.
Publicado: (2018)

Recognizing the cooperative and independent mitochondrial functions of Parkin and PINK1
por: Johnson, Bethann N., et al.
Publicado: (2012)

Regulation of mitochondrial function by PINK1, Parkin and DJ-1
por: Giaime, Emilie, et al.
Publicado: (2013)

Loss of iron triggers PINK1/Parkin-independent mitophagy
por: Allen, George F G, et al.
Publicado: (2013)

Hexokinases link DJ-1 to the PINK1/parkin pathway
por: Hauser, David N., et al.
Publicado: (2017)

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration
por: Newman, Laura E., et al.
Publicado: (2018)

Structural basis for feedforward control in the PINK1/Parkin pathway
por: Sauvé, Véronique, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_hdm2ibc5j9euokm3o2cp2lnn41