A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation

BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks (DSBs), mediators including ATM are recruited...

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Detalles Bibliográficos
Autores principales: Valentine, Jane M, Kumar, Sonia, Moumen, Abdeladim
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050855/
https://www.ncbi.nlm.nih.gov/pubmed/21338495
http://dx.doi.org/10.1186/1471-2407-11-79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050855/
https://www.ncbi.nlm.nih.gov/pubmed/21338495
http://dx.doi.org/10.1186/1471-2407-11-79

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