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A p53-independent role for the MDM2 antagonist Nutlin-3 in DNA damage response initiation
BACKGROUND: The mammalian DNA-damage response (DDR) has evolved to protect genome stability and maximize cell survival following DNA-damage. One of the key regulators of the DDR is p53, itself tightly regulated by MDM2. Following double-strand DNA breaks (DSBs), mediators including ATM are recruited...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3050855/ https://www.ncbi.nlm.nih.gov/pubmed/21338495 http://dx.doi.org/10.1186/1471-2407-11-79 |