Interaction of diltiazem with an intracellularly accessible binding site on Ca(V)1.2

BACKGROUND AND PURPOSE: Diltiazem inhibits Ca(V)1.2 channels and is widely used in clinical practice to treat cardiovascular diseases. Binding determinants for diltiazem are located on segments IIIS6, IVS6 and the selectivity filter of the pore forming α(1) subunit of Ca(V)1.2. The aim of the presen...

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Detalles Bibliográficos
Autores principales: Shabbir, W, Beyl, S, Timin, EN, Schellmann, D, Erker, T, Hohaus, A, Hockerman, GH, Hering, S
Formato: Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2011
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051262/
https://www.ncbi.nlm.nih.gov/pubmed/20973779
http://dx.doi.org/10.1111/j.1476-5381.2010.01091.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051262/
https://www.ncbi.nlm.nih.gov/pubmed/20973779
http://dx.doi.org/10.1111/j.1476-5381.2010.01091.x

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