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Interaction of diltiazem with an intracellularly accessible binding site on Ca(V)1.2
BACKGROUND AND PURPOSE: Diltiazem inhibits Ca(V)1.2 channels and is widely used in clinical practice to treat cardiovascular diseases. Binding determinants for diltiazem are located on segments IIIS6, IVS6 and the selectivity filter of the pore forming α(1) subunit of Ca(V)1.2. The aim of the presen...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Blackwell Science Inc
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051262/ https://www.ncbi.nlm.nih.gov/pubmed/20973779 http://dx.doi.org/10.1111/j.1476-5381.2010.01091.x |