Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy

BACKGROUND AND PURPOSE: Conventional determination of agonist efficacy at G-protein coupled receptors is measured by stimulation of guanosine-5′-γ−thiotriphosphate (GTPγS) binding. We analysed the role of guanosine diphosphate (GDP) in the process of activation of the M(2) muscarinic acetylcholine r...

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Detalles Bibliográficos
Autores principales: Jakubík, J, Janíčková, H, El-Fakahany, EE, Doležal, V
Formato: Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2011
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051377/
https://www.ncbi.nlm.nih.gov/pubmed/20958290
http://dx.doi.org/10.1111/j.1476-5381.2010.01081.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051377/
https://www.ncbi.nlm.nih.gov/pubmed/20958290
http://dx.doi.org/10.1111/j.1476-5381.2010.01081.x

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