Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model

Mitochondrial complex I dysfunction is regarded as underlying dopamine neuron death in Parkinson’s disease models. However, inactivation of the Ndufs4 gene, which compromises complex I activity, does not affect the survival of dopamine neurons in culture or in the substantia nigra pars compacta of 5...

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Detalles Bibliográficos
Autores principales: Choi, Won-Seok, Palmiter, Richard D., Xia, Zhengui
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051820/
https://www.ncbi.nlm.nih.gov/pubmed/21383081
http://dx.doi.org/10.1083/jcb.201009132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3051820/
https://www.ncbi.nlm.nih.gov/pubmed/21383081
http://dx.doi.org/10.1083/jcb.201009132

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