Cargando…

Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion

AIMS/HYPOTHESIS: We assessed whether per-arnt-sim (PAS) domain-containing protein kinase (PASK) is involved in the regulation of glucagon secretion. METHODS: mRNA levels were measured in islets by quantitative PCR and in pancreatic beta cells obtained by laser capture microdissection. Glucose tolera...

Descripción completa

Detalles Bibliográficos
Autores principales:	da Silva Xavier, G., Farhan, H., Kim, H., Caxaria, S., Johnson, P., Hughes, S., Bugliani, M., Marselli, L., Marchetti, P., Birzele, F., Sun, G., Scharfmann, R., Rutter, J., Siniakowicz, K., Weir, G., Parker, H., Reimann, F., Gribble, F. M., Rutter, G. A.
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052475/ https://www.ncbi.nlm.nih.gov/pubmed/21181396 http://dx.doi.org/10.1007/s00125-010-2010-7

Ejemplares similares

Human Mutation within Per-Arnt-Sim (PAS) Domain-containing Protein Kinase (PASK) Causes Basal Insulin Hypersecretion
por: Semplici, Francesca, et al.
Publicado: (2011)

Prostaglandins as Candidate Ligands for a Per-ARNT-Sim (PAS) Domain of Steroid Receptor Coactivator 1 (SRC1)
por: Daffern, Nicolas, et al.
Publicado: (2023)

Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function
por: Bersten, David C., et al.
Publicado: (2014)

Reciprocal regulation of the basic helix–loop–helix/Per–Arnt–Sim partner proteins, Arnt and Arnt2, during neuronal differentiation
por: Hao, Nan, et al.
Publicado: (2013)

Identification of Small Molecule Ligand Binding Sites On and In the ARNT PAS-B Domain
por: Xu, Xingjian, et al.
Publicado: (2023)

Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic β-Cells
por: Fontés, Ghislaine, et al.
Publicado: (2009)

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis
por: Tesi, Marta, et al.
Publicado: (2021)

The Role of PAS Kinase in PASsing the Glucose Signal
por: Grose, Julianne H., et al.
Publicado: (2010)

Fostering improved human islet research: a European perspective
por: Marchetti, Piero, et al.
Publicado: (2019)

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors
por: Wu, Dalei, et al.
Publicado: (2016)

Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR
por: Hao, Nan, et al.
Publicado: (2011)

Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family
por: Sun, Xiangnan, et al.
Publicado: (2022)

Per-Arnt-Sim Kinase (PASK): An Emerging Regulator of Mammalian Glucose and Lipid Metabolism
por: Zhang, Dan-dan, et al.
Publicado: (2015)

Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion
por: Parker, H. E., et al.
Publicado: (2012)

Reconstruction of ARNT PAS-B Unfolding Pathways by Steered Molecular Dynamics and Artificial Neural Networks
por: Motta, Stefano, et al.
Publicado: (2021)

Carbohydrate-Responsive Element-Binding Protein (ChREBP) Is a Negative Regulator of ARNT/HIF-1β Gene Expression in Pancreatic Islet β-Cells
por: Noordeen, Nafeesa A., et al.
Publicado: (2010)

Electrical activity-triggered glucagon-like peptide-1 secretion from primary murine L-cells
por: Rogers, G J, et al.
Publicado: (2011)

The Human and Mouse Islet Peptidome: Effects of Obesity and Type 2 Diabetes, and Assessment of Intraislet Production of Glucagon-like Peptide-1
por: Galvin, Sam G., et al.
Publicado: (2021)

ADCY5 Couples Glucose to Insulin Secretion in Human Islets
por: Hodson, David J., et al.
Publicado: (2014)

Palmitate Activates Autophagy in INS-1E β-Cells and in Isolated Rat and Human Pancreatic Islets
por: Martino, Luisa, et al.
Publicado: (2012)

Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis
por: Swiatek, Wojciech, et al.
Publicado: (2020)

Regulating Glucagon Secretion: Somatostatin in the Spotlight
por: Rutter, Guy A.
Publicado: (2009)

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production
por: Semplici, Francesca, et al.
Publicado: (2016)

Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells
por: Habib, A. M., et al.
Publicado: (2013)

Unsaturated fatty acids as high-affinity ligands of the C-terminal Per-ARNT-Sim domain from the Hypoxia-inducible factor 3α
por: Fala, Angela M., et al.
Publicado: (2015)

Incretin-Modulated Beta Cell Energetics in Intact Islets of Langerhans
por: Hodson, David J., et al.
Publicado: (2014)

The bHLH/Per-Arnt-Sim transcription factor SIM2 regulates muscle transcript myomesin2 via a novel, non-canonical E-box sequence
por: Woods, Susan, et al.
Publicado: (2008)

Mechanisms underlying glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 secretion
por: Reimann, Frank, et al.
Publicado: (2016)

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose
por: Johnston, Natalie R., et al.
Publicado: (2016)

An α/β Hydrolase and Associated Per-ARNT-Sim Domain Comprise a Bipartite Sensing Module Coupled with Diverse Output Domains
por: Nadezhdin, Eugene V., et al.
Publicado: (2011)

Decreased expression of neuronal Per-Arnt-Sim domain protein 4 gene in the hippocampus of a post-stroke depression rat model
por: ZHANG, ZHAOHUI, et al.
Publicado: (2014)

Small molecule glucagon release inhibitors with activity in human islets
por: Kalwat, Michael A., et al.
Publicado: (2023)

Organ donor pancreases for the study of human islet cell histology and pathophysiology: a precious and valuable resource
por: Marchetti, Piero, et al.
Publicado: (2018)

Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets
por: Ciregia, Federica, et al.
Publicado: (2017)

Pancreatic Beta Cell Identity in Humans and the Role of Type 2 Diabetes
por: Marchetti, Piero, et al.
Publicado: (2017)

Lymphoid malignancies ARNT unstoppable
por: Gardella, Kacie A., et al.
Publicado: (2016)

Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation
por: Corrada, Dario, et al.
Publicado: (2016)

Increased expression of miR-187 in human islets from individuals with type 2 diabetes is associated with reduced glucose-stimulated insulin secretion
por: Locke, J. M., et al.
Publicado: (2013)

Per-Arnt-Sim Kinase (PASK) Deficiency Increases Cellular Respiration on a Standard Diet and Decreases Liver Triglyceride Accumulation on a Western High-Fat High-Sugar Diet
por: Pape, Jenny A., et al.
Publicado: (2018)

Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius: Electrical Properties of Glucagon-Like Peptide 1 Neurons
por: Hisadome, Kazunari, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_cv8r2gqnbta94f3qmqnhvmihp4