Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements

Here, we demonstrate that in HeLa cells, Ser317 of Chk1 undergoes phosphorylation in response to replication stress induced by hydroxyurea. We also demonstrate the existence of constitutive (interphase and mitotic) Chk1 kinase phosphorylation, the translocation of its phosphorylated form from the nu...

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Detalles Bibliográficos
Autores principales: Rybaczek, Dorota, Kowalewicz-Kulbat, Magdalena
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052479/
https://www.ncbi.nlm.nih.gov/pubmed/21347609
http://dx.doi.org/10.1007/s00418-011-0793-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052479/
https://www.ncbi.nlm.nih.gov/pubmed/21347609
http://dx.doi.org/10.1007/s00418-011-0793-3

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