Mutations in modified virus Ankara protein 183 render it a non-functional counterpart of B14, an inhibitor of nuclear factor κB activation

Vaccinia virus (VACV) encodes multiple proteins to evade host innate immunity, including B14, a virulence factor that binds to the inhibitor of κB kinase β (IKKβ) and blocks nuclear factor κB (NF-κB) activation. B14 shares 95 % amino acid identity with the 183 protein encoded by modified virus Ankar...

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Detalles Bibliográficos
Autores principales: McCoy, Laura E., Fahy, Aodhnait S., Chen, Ron A.-J., Smith, Geoffrey L.
Formato: Texto
Lenguaje:English
Publicado: Society for General Microbiology 2010
Materias:
Animal
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052518/
https://www.ncbi.nlm.nih.gov/pubmed/20444990
http://dx.doi.org/10.1099/vir.0.022343-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052518/
https://www.ncbi.nlm.nih.gov/pubmed/20444990
http://dx.doi.org/10.1099/vir.0.022343-0

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