Conformational Sampling and Nucleotide-Dependent Transitions of the GroEL Subunit Probed by Unbiased Molecular Dynamics Simulations

GroEL is an ATP dependent molecular chaperone that promotes the folding of a large number of substrate proteins in E. coli. Large-scale conformational transitions occurring during the reaction cycle have been characterized from extensive crystallographic studies. However, the link between the observ...

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Detalles Bibliográficos
Autores principales: Skjaerven, Lars, Grant, Barry, Muga, Arturo, Teigen, Knut, McCammon, J. Andrew, Reuter, Nathalie, Martinez, Aurora
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053311/
https://www.ncbi.nlm.nih.gov/pubmed/21423709
http://dx.doi.org/10.1371/journal.pcbi.1002004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053311/
https://www.ncbi.nlm.nih.gov/pubmed/21423709
http://dx.doi.org/10.1371/journal.pcbi.1002004

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