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Global Developmental Gene Expression and Pathway Analysis of Normal Brain Development and Mouse Models of Human Neuronal Migration Defects

Heterozygous LIS1 mutations are the most common cause of human lissencephaly, a human neuronal migration defect, and DCX mutations are the most common cause of X-linked lissencephaly. LIS1 is part of a protein complex including NDEL1 and 14-3-3ε that regulates dynein motor function and microtubule d...

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Detalles Bibliográficos
Autores principales: Pramparo, Tiziano, Libiger, Ondrej, Jain, Sonia, Li, Hong, Youn, Yong Ha, Hirotsune, Shinji, Schork, Nicholas J., Wynshaw-Boris, Anthony
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053345/
https://www.ncbi.nlm.nih.gov/pubmed/21423666
http://dx.doi.org/10.1371/journal.pgen.1001331