Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1

[Image: see text] Kinome-wide selectivity profiling of a collection of 2-amino-pyrido[2,3-d]pyrimidines followed by cellular structure−activity relationship-guided optimization resulted in the identification of moderately potent and selective inhibitors of BMK1/ERK5 exemplified by 11, 18, and 21. Fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Deng, Xianming, Yang, Qingkai, Kwiatkowski, Nicholas, Sim, Taebo, McDermott, Ultan, Settleman, Jeffrey E., Lee, Jiing-Dwan, Gray, Nathanael S.
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055678/
https://www.ncbi.nlm.nih.gov/pubmed/21412406
http://dx.doi.org/10.1021/ml100304b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055678/
https://www.ncbi.nlm.nih.gov/pubmed/21412406
http://dx.doi.org/10.1021/ml100304b

Ejemplares similares