Cargando…

Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1

[Image: see text] Kinome-wide selectivity profiling of a collection of 2-amino-pyrido[2,3-d]pyrimidines followed by cellular structure−activity relationship-guided optimization resulted in the identification of moderately potent and selective inhibitors of BMK1/ERK5 exemplified by 11, 18, and 21. Fo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deng, Xianming, Yang, Qingkai, Kwiatkowski, Nicholas, Sim, Taebo, McDermott, Ultan, Settleman, Jeffrey E., Lee, Jiing-Dwan, Gray, Nathanael S.
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055678/ https://www.ncbi.nlm.nih.gov/pubmed/21412406 http://dx.doi.org/10.1021/ml100304b

Ejemplares similares

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones
por: Deng, Xianming, et al.
Publicado: (2013)

One-pot synthesis of novel 1H-pyrimido[4,5-c][1,2]diazepines and pyrazolo[3,4-d]pyrimidines
por: Prajapati, Dipak, et al.
Publicado: (2006)

Bicyclic 6 + 6 systems: the chemistry of pyrimido[4,5-d]pyrimidines and pyrimido[5,4-d]pyrimidines
por: Monier, M., et al.
Publicado: (2019)

1,5-Dibenzyl-3-propargyl-1,5-benzodiazepine-2,4-dione
por: Jabli, Hind, et al.
Publicado: (2009)

Synthesis and biological evaluation of the new ring system benzo[f]pyrimido[1,2-d][1,2,3]triazolo[1,5-a][1,4]diazepine and its cycloalkane and cycloalkene condensed analogues
por: El Haimer, Mohamed, et al.
Publicado: (2021)

Crystal structure of (1Z,4Z)-2,4-dimethyl-3H-benzo[b][1,4]diazepine
por: Nieto, Carla I., et al.
Publicado: (2017)

Regiospecific Synthesis and Structural Studies of 3,5-Dihydro-4H-pyrido[2,3-b][1,4]diazepin-4-ones and Comparison with 1,3-Dihydro-2H-benzo[b][1,4]diazepin-2-ones
por: Núñez Alonso, David, et al.
Publicado: (2020)

Identification of Substituted Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands
por: Chan, Michael, et al.
Publicado: (2013)

4-(Piperidin-1-yl)-4H-benzo[b]tetrazolo[1,5-d][1,4]diazepin-5(6H)-one
por: Nichol, Gary S., et al.
Publicado: (2010)

(11-Methylpyrido[2,3-b][1,4]benzodiazepin-6-yl)(phenyl)methanone
por: Shi, Fuqiang, et al.
Publicado: (2010)

Mechanism of falcipain-2 inhibition by α,β-unsaturated benzo[1,4]diazepin-2-one methyl ester
por: Grazioso, Giovanni, et al.
Publicado: (2012)

An Efficient Synthetic Approach Towards Benzo[b]pyrano[2,3-e][1,4]diazepines, and Their Cytotoxic Activity
por: El Azab, Islam H., et al.
Publicado: (2020)

Crystal structure of 2,2,4-trimethyl-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepine hemihydrate
por: Ezhilarasi, K. S., et al.
Publicado: (2015)

3-Hexadecyl-1,5-dimethyl-1H-1,5-benzodiazepine-2,4(3H,5H)-dione
por: Dardouri, Rachida, et al.
Publicado: (2011)

2,2,4-Trimethyl-5-(4-tolylsulfonyl)-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
por: Ravichandran, K., et al.
Publicado: (2009)

1-Ethoxymethyl-5-methyl-9-phenyl-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4(3H,5H)-dione
por: Li, Gong, et al.
Publicado: (2012)

Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones
por: Iribarra, Jennyfer, et al.
Publicado: (2012)

Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives
por: Loidreau, Yvonnick, et al.
Publicado: (2020)

3′-(3-Hydroxyphenyl)-4-methylspiro[benzo[e][1,4]diazepine-3,2′-oxirane]-2,5(1H,4H)-dione
por: Liu, Jun-Liang, et al.
Publicado: (2011)

Synthesis of new tricyclic 5,6-dihydro-4H-benzo[b][1,2,4]triazolo[1,5-d][1,4]diazepine derivatives by [3(+) + 2]-cycloaddition/rearrangement reactions
por: Luan, Lin-bo, et al.
Publicado: (2018)

2-Butyl-11-phenyl-5,10-dihydro-1H-benzo[e]imidazo[1,5-a][1,4]diazepine-1,3(2H)-dione
por: Nichol, Gary S., et al.
Publicado: (2010)

5,7-Dimethyl-2,3-dihydro-1H-1,4-diazepin-4-ium picrate
por: Jasinski, Jerry P., et al.
Publicado: (2010)

Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent
por: El-Kalyoubi, Samar A.
Publicado: (2018)

Racemic 9,10-dimethoxy-3-methyl-6-phenyl-7,7a-dihydrobenzo[b]benzo[4,5]isothiazolo[2,3-d][1,4]diazepine 12,12-dioxide
por: Bassin, Jatinder P., et al.
Publicado: (2011)

2,4-Diphenyl-4,5-dihydro-3H-pyrido[2,3-b][1,4]diazepine
por: Fun, Hoong-Kun, et al.
Publicado: (2009)

Crystal structure of ethyl 4-(2-chlorophenyl)-2-methyl-4H-pyrimido[2,1-b][1,3]benzothiazole-3-carboxylate
por: Kumar, Balbir, et al.
Publicado: (2015)

6-Methylsulfanyl-4H-pyrimido[1,6-a]pyrimidin-4-one
por: Huang, Quinhua, et al.
Publicado: (2009)

Ethyl {4-[(1,5-dimethyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)methyl]-1,2,3-triazol-1-yl}acetate
por: Dardouri, Rachida, et al.
Publicado: (2010)

Synthesis of Substituted 1,4-Diazepines and 1,5-Benzodiazepines Using an Efficient Heteropolyacid-Catalyzed Procedure
por: Kaoua, Rachedine, et al.
Publicado: (2010)

Di-μ-chlorido-bis[chlorido(1,4,6-trimethyl-6-nitro-1,4-diazepine)copper(II)]
por: Bortoluzzi, Adailton J., et al.
Publicado: (2009)

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors
por: Deng, Xianming, et al.
Publicado: (2011)

Identification of Thiazolo[5,4-b]pyridine Derivatives as c-KIT Inhibitors for Overcoming Imatinib Resistance
por: Nam, Yunju, et al.
Publicado: (2022)

New Insight into the SAR of Pyrimido [4,5-b][1,4] Benzothiazines as 15-lipoxygenase Inhibitors
por: Pooryaghoobi, Nona, et al.
Publicado: (2013)

rac-(3S,4S)-3-Hydroxy-4-phenyl-1-[(S)-(3-phenyl-4,5-dihydro-1,2-oxazol-5-yl)methyl]-4,5-dihydro-1H-1,5-benzodiazepin-2(3H)-one
por: Rida, Mohamed, et al.
Publicado: (2011)

Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2
por: Deng, Xianming, et al.
Publicado: (2011)

Ethyl 2-{4-[(1,5-dibenzyl-2,4-dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl)methyl]-1H-1,2,3-triazol-1-yl}acetate
por: Jabli, Hind, et al.
Publicado: (2009)

A New 1,4-Diazepine from South China Sea Marine Sponge Callyspongia Species
por: Huang, Ri-Ming, et al.
Publicado: (2010)

4-Phenyl-1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazol-2-one
por: Li, Gong-Chun, et al.
Publicado: (2008)

3-Methylbenzo[1,2-c:5,4-c′]dichromen-6(8H)-one
por: Kayalvizhi, M., et al.
Publicado: (2014)

10,10′-Methylenebis[2,3-dihydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-5,11(10H,11aH)-dione] dihydrate
por: Benzeid, Hanane, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_u775r8liaev5f8c3khtquh475i