Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

We have previously demonstrated that brief treatment of APP transgenic mice with metal ionophores (PBT2, Prana Biotechnology) rapidly and markedly improves learning and memory. To understand the potential mechanisms of action underlying this phenomenon we examined hippocampal dendritic spine density...

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Detalles Bibliográficos
Autores principales: Adlard, Paul A., Bica, Laura, White, Anthony R., Nurjono, Milawaty, Filiz, Gulay, Crouch, Peter J., Donnelly, Paul S., Cappai, Roberto, Finkelstein, David I., Bush, Ashley I.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055881/
https://www.ncbi.nlm.nih.gov/pubmed/21412423
http://dx.doi.org/10.1371/journal.pone.0017669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055881/
https://www.ncbi.nlm.nih.gov/pubmed/21412423
http://dx.doi.org/10.1371/journal.pone.0017669

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