A Live-Attenuated HSV-2 ICP0 (−) Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine

Glycoprotein D (gD-2) is the entry receptor of herpes simplex virus 2 (HSV-2), and is the immunogen in the pharmaceutical industry's lead HSV-2 vaccine candidate. Efforts to prevent genital herpes using gD-2 subunit vaccines have been ongoing for 20 years at a cost in excess of $100 million. To...

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Detalles Bibliográficos
Autores principales: Halford, William P., Püschel, Ringo, Gershburg, Edward, Wilber, Andrew, Gershburg, Svetlana, Rakowski, Brandon
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055896/
https://www.ncbi.nlm.nih.gov/pubmed/21412438
http://dx.doi.org/10.1371/journal.pone.0017748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055896/
https://www.ncbi.nlm.nih.gov/pubmed/21412438
http://dx.doi.org/10.1371/journal.pone.0017748

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