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A Live-Attenuated HSV-2 ICP0 (−) Virus Elicits 10 to 100 Times Greater Protection against Genital Herpes than a Glycoprotein D Subunit Vaccine
Glycoprotein D (gD-2) is the entry receptor of herpes simplex virus 2 (HSV-2), and is the immunogen in the pharmaceutical industry's lead HSV-2 vaccine candidate. Efforts to prevent genital herpes using gD-2 subunit vaccines have been ongoing for 20 years at a cost in excess of $100 million. To...
Autores principales: | Halford, William P., Püschel, Ringo, Gershburg, Edward, Wilber, Andrew, Gershburg, Svetlana, Rakowski, Brandon |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055896/ https://www.ncbi.nlm.nih.gov/pubmed/21412438 http://dx.doi.org/10.1371/journal.pone.0017748 |
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