Activation of K-RAS by co-mutation of codons 19 and 20 is transforming

The K-RAS oncogene is widely mutated in human cancers. Activating mutations in K-RAS give rise to constitutive signalling through the MAPK/ERK and PI3K/AKT pathways promoting increased cell division, reduced apoptosis and transformation. The majority of activating mutations in K-RAS are located in c...

Descripción completa

Detalles Bibliográficos
Autores principales: Naguib, Adam, Wilson, Catherine H, Adams , David J, Arends, Mark J
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056876/
https://www.ncbi.nlm.nih.gov/pubmed/21371307
http://dx.doi.org/10.1186/1750-2187-6-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056876/
https://www.ncbi.nlm.nih.gov/pubmed/21371307
http://dx.doi.org/10.1186/1750-2187-6-2

Ejemplares similares