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The pluripotency factor, Oct4, interacts with Ctcf and also controls X-chromosome pairing and counting
Pluripotency of embryonic stem (ES) cells is controlled by defined transcription factors1,2. During differentiation, mouse ES cells undergo global epigenetic reprogramming, as exemplified by X-chromosome inactivation (XCI) whereby one female X-chromosome is silenced to achieve gene dosage parity bet...
| Autores principales: | , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057664/ https://www.ncbi.nlm.nih.gov/pubmed/19536159 http://dx.doi.org/10.1038/nature08098 |