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Noninvasive multi–photon fluorescence microscopy resolves retinol and retinal–condensation products in mouse eyes

Multi–photon excitation fluorescence microscopy (MPM) can image certain molecular processes in vivo. In the eye, fluorescent retinyl esters in sub–cellular structures called retinosomes mediate regeneration of the visual chromophore, 11–cis–retinal, by the visual cycle. But harmful fluorescent conde...

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Detalles Bibliográficos
Autores principales: Palczewska, Grazyna, Maeda, Tadao, Imanishi, Yoshikazu, Sun, Wenyu, Chen, Yu, Williams, David R., Piston, David, Maeda, Akiko, Palczewski, Krzysztof
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057900/
https://www.ncbi.nlm.nih.gov/pubmed/21076393
http://dx.doi.org/10.1038/nm.2260