Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans

BACKGROUND: Preventing germline stem cell proliferation extends lifespan in nematodes and flies. So far, studies on germline-longevity signaling have focused on daf-16/FOXO and daf-12/VDR. Here, we report on NHR-80/HNF4, a nuclear receptor that specifically mediates longevity induced by depletion of...

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Detalles Bibliográficos
Autores principales: Goudeau, Jérôme, Bellemin, Stéphanie, Toselli-Mollereau, Esther, Shamalnasab, Mehrnaz, Chen, Yiqun, Aguilaniu, Hugo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057950/
https://www.ncbi.nlm.nih.gov/pubmed/21423649
http://dx.doi.org/10.1371/journal.pbio.1000599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057950/
https://www.ncbi.nlm.nih.gov/pubmed/21423649
http://dx.doi.org/10.1371/journal.pbio.1000599

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